DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to enhance DNA uptake. Here, we discuss additional immunological effects of electroporation that are key aspects for inducing immunity in response to DNA vaccines.
Keywords: ATP; DAMPs; T lymphocyte; dendritic cell; electric pulses; electropermeabilization; gene electrotransfer; immunotherapy; non-viral gene therapy.