Electronic readout enzyme-linked immunosorbent assay with organic field-effect transistors as a preeclampsia prognostic

Adv Mater. 2014 Sep 17;26(35):6138-44. doi: 10.1002/adma.201401829. Epub 2014 Jul 22.

Abstract

Organic field-effect transistor (OFET) sensors can meet the need for portable and real-time diagnostics. An electronicreadout enzyme-linked immunosorbent assay using OFETs for the detection of a panel of three biomarkers in complex media to create a pre-eclampsia prognostic is demonstrated, along with biodetection utilizing a fully inkjet-printed and flexible OFET to underscore our ability to produce disposable devices.

Keywords: biodetection; organic field-effect transistors; preeclampsia; serum.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies / immunology
  • Biomarkers / blood
  • Enzyme-Linked Immunosorbent Assay
  • Enzymes, Immobilized / chemistry
  • Enzymes, Immobilized / metabolism
  • Female
  • Glucose Oxidase / chemistry
  • Glucose Oxidase / metabolism
  • Humans
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / metabolism
  • Pregnancy
  • Prognosis
  • Transistors, Electronic*
  • Vascular Endothelial Growth Factor Receptor-1 / blood
  • Vascular Endothelial Growth Factor Receptor-1 / immunology

Substances

  • Antibodies
  • Biomarkers
  • Enzymes, Immobilized
  • Glucose Oxidase
  • Vascular Endothelial Growth Factor Receptor-1