[Pristinamycin/Vitamin k antagonists drug interaction: a French pharmacovigilance database study]

Therapie. 2014 Sep-Oct;69(5):391-4. doi: 10.2515/therapie/2014033. Epub 2014 Jul 23.
[Article in French]

Abstract

Objective: To analyse pristinamycin/vitamin K antagonists (VKA) drug interaction by using data recorded in the French pharmacovigilance database (FPVB).

Methods: All cases with an increase effect of a VKA and an association with pristinamycin recorded in the FPVB between 1985 and 2013 were included. Data concerning patients, VKA treatments and side effects were recorded for a descriptive analysis.

Results: During this period, 31 reports with a VKA overdose after an association with pristinamycin were included. Fluindione is the most often involved VKA (77% of cases). In 20 cases (65.4%), VKA overdose caused bleeding and 24 cases (77.4%) were serious.

Conclusion: Although mechanism is unknown, pristinamycine/AVK drug interaction is a reality that needs to be reported in the summary of product characteristics of these drugs and better known by practitioners to act in patients' interest.

Publication types

  • English Abstract

MeSH terms

  • 4-Hydroxycoumarins* / administration & dosage
  • 4-Hydroxycoumarins* / adverse effects
  • Adult
  • Adverse Drug Reaction Reporting Systems / statistics & numerical data
  • Aged
  • Aged, 80 and over
  • Databases, Factual*
  • Drug Interactions
  • Female
  • France / epidemiology
  • Humans
  • Indenes* / administration & dosage
  • Indenes* / adverse effects
  • Male
  • Middle Aged
  • Pharmacovigilance*
  • Pristinamycin* / administration & dosage
  • Pristinamycin* / adverse effects
  • Vitamin K / administration & dosage
  • Vitamin K / adverse effects
  • Vitamin K / antagonists & inhibitors*

Substances

  • 4-Hydroxycoumarins
  • Indenes
  • Pristinamycin
  • antivitamins K
  • Vitamin K