Abstract
A phytochemical investigation on the peels of Clausena lansium (Lour.) Skeels led to the isolation of two new monoterpenoid coumarins, named clauslactone V (1) and clauslactone W (2), together with three known analogues (3-5). Their structures were elucidated by spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). All the compounds were evaluated for hypoglycemic activity, and compounds 1-5 showed α-glucosidase inhibitory activity in vitro.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Clausena / chemistry*
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology*
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Fruit / chemistry
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Glycoside Hydrolase Inhibitors / chemistry
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Glycoside Hydrolase Inhibitors / isolation & purification
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Glycoside Hydrolase Inhibitors / pharmacology*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology*
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification
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Monoterpenes / pharmacology*
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Plants, Medicinal
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alpha-Glucosidases / drug effects
Substances
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Coumarins
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Drugs, Chinese Herbal
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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Monoterpenes
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clauslactone V
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clauslactone W
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alpha-Glucosidases