Macromolecule loading into spherical, elliptical, star-like and cubic calcium carbonate carriers

Abstract

We fabricated calcium carbonate particles with spherical, elliptical, star-like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star-like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted.

Keywords: adsorption; calcium; drug delivery; nanoparticles; solid-state structures.