Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

Chem Biodivers. 2014 Jul;11(7):1053-68. doi: 10.1002/cbdv.201300259.

Abstract

Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

Keywords: Anti-HSV-1 activity; Anti-inflammatory activity; Schisandra sphenanthera; Sesquiterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Fruit / chemistry*
  • Herpes Simplex / drug therapy
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • Models, Molecular
  • Neutrophils / drug effects
  • Neutrophils / immunology
  • Schisandra / chemistry*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Antiviral Agents
  • Sesquiterpenes