Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery

Adv Mater. 2014 Sep 17;26(35):6174-80. doi: 10.1002/adma.201401931. Epub 2014 Jul 17.

Abstract

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.

Keywords: biodegradable; cancer; disulfide; drug delivery; nanoparticles; periodic mesoporous organosilica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / toxicity
  • Cell Survival / drug effects
  • Disulfides / chemistry*
  • Doxorubicin / chemistry
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • Ethylenes / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • MCF-7 Cells
  • Nanospheres / chemistry*
  • Nanotubes / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Antibiotics, Antineoplastic
  • Disulfides
  • Drug Carriers
  • Ethylenes
  • Silicon Dioxide
  • Doxorubicin
  • ethylene