Inflammatory interference of memory formation

Trends Immunol. 2014 Aug;35(8):355-7. doi: 10.1016/j.it.2014.07.001. Epub 2014 Jul 17.

Abstract

CD8+ memory T cells are critical for immunity against intracellular pathogens. Epidemiological evidence demonstrates that bystander infection can impact immune responses to co-infection or vaccination. A recent paper in Immunity demonstrates that persistent bystander inflammation can negatively impact CD8+ T cell effector to memory transition and protection from subsequent infection.

Publication types

  • Introductory Journal Article

MeSH terms

  • Animals
  • Bystander Effect* / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Differentiation
  • Cellular Microenvironment
  • Chronic Disease
  • Coinfection
  • Humans
  • Immunologic Memory*
  • Inflammation / immunology*
  • Mice
  • Vaccines

Substances

  • Vaccines