Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging

Dig Endosc. 2015 Mar;27(3):392-6. doi: 10.1111/den.12331. Epub 2014 Aug 28.

Abstract

White opaque substance (WOS) is observed in the gastric neoplasia of 0-IIa type using magnifying endoscopy with narrow band imaging (NBI-ME). Colonic and duodenal neoplasms with WOS have also been reported. Immunohistochemical examination with adipophilin reveals WOS in gastric neoplasms as lipid droplets, and WOS is specific for neoplasm with intestinal or gastrointestinal phenotype. We herein report a case of adenocarcinoma of the esophagogastric junction with WOS. A male patient in his sixties was found by esophagogastroduodenoscopy to have an esophageal elevated lesion. NBI-ME showed whitish deposits that looked similar to WOS in gastric neoplasms. The patient underwent endoscopic submucosal dissection and the lesion was resected in a single piece. This tumor had diffuse positivity for adipophilin and gastrointestinal phenotype.

Keywords: adenocarcinoma; esophageal cancer; magnifying endoscopy; narrow band imaging (NBI); white opaque substance (WOS).

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Biopsy, Needle
  • Dissection / methods
  • Esophageal Neoplasms / pathology*
  • Esophageal Neoplasms / surgery
  • Esophagogastric Junction / pathology*
  • Esophagoscopes
  • Esophagoscopy / instrumentation
  • Esophagoscopy / methods*
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Narrow Band Imaging*
  • Risk Assessment
  • Treatment Outcome

Supplementary concepts

  • Adenocarcinoma Of Esophagus