Failure of heterogeneous amyloid-enhancing factor in geriatric squirrel monkeys (Saimiri boliviensis)

J Med Primatol. 2014 Dec;43(6):488-91. doi: 10.1111/jmp.12136. Epub 2014 Jul 19.

Abstract

Background: Cross-species transmission of AA amyloidosis between primates and other animals has not been previously reported.

Methods: Eight geriatric squirrel monkeys were intravenously administered chimpanzee, bovine, or chicken amyloid fibrils and simultaneously received inflammatory stimulation.

Results: AA amyloid deposition was not detected in any of the monkeys histopathologically or immunohistochemically.

Conclusions: These results suggest that heterogeneous AA amyloidosis may not be easily transmitted into primates.

Keywords: AA amyloidosis; amyloid A; amyloid β; cattle; chicken; chimpanzee; transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravenous / veterinary
  • Aging*
  • Amyloid / administration & dosage
  • Amyloid / metabolism*
  • Amyloidosis / etiology
  • Amyloidosis / therapy
  • Amyloidosis / veterinary*
  • Animals
  • Cattle / physiology
  • Chickens / physiology
  • Female
  • Glycoproteins / administration & dosage
  • Glycoproteins / metabolism*
  • Male
  • Pan troglodytes / physiology
  • Saimiri / physiology*

Substances

  • Amyloid
  • Glycoproteins
  • amyloid enhancing factor