Guidance for peptide vaccines for the treatment of cancer

Cancer Sci. 2014 Jul;105(7):924-31. doi: 10.1111/cas.12443.

Abstract

Recent progress in fundamental understanding of tumor immunology has opened a new avenue of cancer vaccines. Currently, the development of new cancer vaccines is a global topic and has attracted attention as one of the most important issues in Japan. There is an urgent need for the development of guidance for cancer vaccine clinical studies in order to lead to drug development. Peptide vaccines characteristically have the effect of indirectly acting against cancer through the immune system - a mechanism of action that clearly differs from anticancer drugs that exert a direct effect. Thus, the clinical development of cancer peptide vaccines should be planned and implemented based on the mechanism of action, which differs significantly from conventional anticancer drug research. The Japanese Society for Biological Therapy has created and published Guidance for peptide vaccines for the treatment of cancer as part of its mission and responsibilities towards cancer peptide vaccine development, which is now pursued globally. We welcome comments from regulators and business people as well as researchers in this area.

Keywords: Cancer vaccines; clinical study; guidance; non-clinical study; peptide vaccines.

Publication types

  • Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cancer Vaccines / pharmacology*
  • Cancer Vaccines / therapeutic use
  • Clinical Trials as Topic
  • Humans
  • Neoplasms / immunology*
  • Neoplasms / therapy
  • Quality Control
  • Vaccines, Subunit / pharmacokinetics
  • Vaccines, Subunit / pharmacology*

Substances

  • Cancer Vaccines
  • Vaccines, Subunit