Aging and age-related diseases--from endocrine therapy to target therapy

Qi Bao; Jie Pan; Hangfei Qi; Lu Wang; Huan Qian; Fangzhen Jiang; Zheren Shao; Fengzhi Xu; Zhiping Tao; Qi Ma; Peter Nelson; Xueqing Hu

doi:10.1016/j.mce.2014.07.005

Aging and age-related diseases--from endocrine therapy to target therapy

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):115-8. doi: 10.1016/j.mce.2014.07.005. Epub 2014 Jul 16.

Authors

Qi Bao¹, Jie Pan², Hangfei Qi³, Lu Wang⁴, Huan Qian⁴, Fangzhen Jiang⁴, Zheren Shao⁴, Fengzhi Xu⁴, Zhiping Tao⁴, Qi Ma⁴, Peter Nelson⁵, Xueqing Hu⁶

Affiliations

¹ Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU), China.
² Department of Endocrinology and Metabolism, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU), China.
³ Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
⁴ Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
⁵ Clinical Biochemistry Group, Medizinische Klinik und Poliklinik IV, University of Munich, Schillerstrasse 42, D-80336 Munich, Germany.
⁶ Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: huxueqing@zju.edu.cn.

PMID: 25038521
DOI: 10.1016/j.mce.2014.07.005

Abstract

Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to hormone-replacement therapy (HRT) that is associated with multiple side effects, including an increased risk of cancer. This has greatly limited the application of HRT in anti-aging therapy. Recently, the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks. In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy.

Keywords: Age-related diseases; Aging; Endocrine; Gene.

Publication types

Review

MeSH terms

Aging / genetics
Aging / metabolism*
Aging / pathology
Cardiovascular Diseases / genetics
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / pathology
Cardiovascular Diseases / therapy*
Diabetes Mellitus / genetics
Diabetes Mellitus / metabolism
Diabetes Mellitus / pathology
Diabetes Mellitus / therapy*
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Glucuronidase / genetics
Glucuronidase / metabolism
Growth Hormone-Releasing Hormone / genetics
Growth Hormone-Releasing Hormone / metabolism
Human Growth Hormone / genetics
Human Growth Hormone / metabolism
Humans
Insulin-Like Growth Factor I / genetics
Insulin-Like Growth Factor I / metabolism
Klotho Proteins
Longevity
Molecular Targeted Therapy
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / pathology
Neoplasms / therapy*
Neurodegenerative Diseases / genetics
Neurodegenerative Diseases / metabolism
Neurodegenerative Diseases / pathology
Neurodegenerative Diseases / therapy*
Osteoporosis / genetics
Osteoporosis / metabolism
Osteoporosis / pathology
Osteoporosis / therapy*
Signal Transduction

Substances

Human Growth Hormone
Insulin-Like Growth Factor I
Growth Hormone-Releasing Hormone
Glucuronidase
Klotho Proteins