Pulmonary arterial hypertension in pregnancy

Semin Perinatol. 2014 Aug;38(5):289-94. doi: 10.1053/j.semperi.2014.04.018. Epub 2014 May 27.

Abstract

Pulmonary hypertension is a medical condition characterized by elevated pulmonary arterial pressure and secondary right heart failure. Pulmonary arterial hypertension is a subset of pulmonary hypertension, which is characterized by an underlying disorder of the pulmonary arterial vasculature. Pulmonary hypertension can also occur secondarily to structural cardiac disease, autoimmune disorders, and toxic exposures. Although pregnancies affected by pulmonary hypertension and pulmonary arterial hypertension are rare, the pathophysiology exacerbated by pregnancy confers both high maternal and fetal mortality and morbidity. In light of new treatment modalities and the use of a multidisciplinary approach to care, maternal outcomes may be improving.

Keywords: Eisenmenger’s syndrome; pregnancy; pulmonary arterial hypertension in pregnancy; pulmonary hypertension.

Publication types

  • Review

MeSH terms

  • Anesthesia, Obstetrical / methods*
  • Bosentan
  • Carbolines
  • Directive Counseling*
  • Epoprostenol
  • Extracorporeal Membrane Oxygenation / methods*
  • Familial Primary Pulmonary Hypertension / complications
  • Familial Primary Pulmonary Hypertension / physiopathology
  • Familial Primary Pulmonary Hypertension / therapy*
  • Female
  • Humans
  • Iloprost
  • Infant, Newborn
  • Piperazines
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / physiopathology
  • Pregnancy Complications, Cardiovascular / therapy*
  • Pregnancy Outcome
  • Pregnancy, High-Risk*
  • Prognosis
  • Pulmonary Circulation
  • Purines
  • Sildenafil Citrate
  • Sulfonamides
  • Tadalafil

Substances

  • Carbolines
  • Piperazines
  • Purines
  • Sulfonamides
  • Tadalafil
  • Sildenafil Citrate
  • Epoprostenol
  • Iloprost
  • Bosentan