Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers

Zhuang Li; Hongliang Kang; Ning Che; Zhijing Liu; Pingping Li; Weiwei Li; Chao Zhang; Chun Cao; Ruigang Liu; Yong Huang

doi:10.1016/j.carbpol.2014.04.017

Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers

Carbohydr Polym. 2014 Oct 13:111:18-24. doi: 10.1016/j.carbpol.2014.04.017. Epub 2014 Apr 18.

Authors

Zhuang Li¹, Hongliang Kang², Ning Che¹, Zhijing Liu¹, Pingping Li¹, Weiwei Li², Chao Zhang¹, Chun Cao¹, Ruigang Liu³, Yong Huang⁴

Affiliations

¹ State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Science, Beijing 100049, China.
² State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
³ State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: rgliu@iccas.ac.cn.
⁴ State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; National Research Center for Engineering Plastics, Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yhuang@mail.ipc.ac.cn.

PMID: 25037324
DOI: 10.1016/j.carbpol.2014.04.017

Abstract

Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials.

Keywords: Cellulose acetate; Core-sheath nanofibers; Electrospinning; Liposomes; Naproxen; Sustained drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Cellulose / analogs & derivatives*
Cellulose / chemistry
Cellulose / ultrastructure
Delayed-Action Preparations / chemistry*
Drug Liberation
Liposomes / chemistry*
Nanofibers / chemistry*
Naproxen / administration & dosage*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Delayed-Action Preparations
Liposomes
acetylcellulose
Naproxen
Cellulose