Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate

Biosci Biotechnol Biochem. 2014;78(3):466-8. doi: 10.1080/09168451.2014.885827. Epub 2014 Apr 16.

Abstract

The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.

Keywords: Panax ginseng; cancer; compound k; polyethylene glycol; solubility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Esters / chemistry
  • Ginsenosides / chemical synthesis*
  • Ginsenosides / chemistry
  • Ginsenosides / pharmacokinetics
  • Hydrogen-Ion Concentration
  • Panax / chemistry*
  • Polyethylene Glycols / chemical synthesis*
  • Polyethylene Glycols / chemistry
  • Surface Properties

Substances

  • Esters
  • Ginsenosides
  • Polyethylene Glycols