Regulatory T cells: exosomes deliver tolerance

Talal A Chatila; Calvin B Williams

doi:10.1016/j.immuni.2014.07.001

Regulatory T cells: exosomes deliver tolerance

Immunity. 2014 Jul 17;41(1):3-5. doi: 10.1016/j.immuni.2014.07.001.

Authors

Talal A Chatila¹, Calvin B Williams²

Affiliations

¹ Division of Immunology, the Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: talal.chatila@childrens.harvard.edu.
² Section of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Abstract

T regulatory (Treg) cells enforce peripheral tolerance through regulation of diverse immune responses in a context-specific manner. Okoye et al. show one way that Treg cells suppress Th1 cell responses is through nonautonomous gene silencing mediated by microRNA-containing exosomes.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Exosomes / genetics
Exosomes / immunology*
Gene Silencing / immunology
Humans
Immune Tolerance / genetics*
Immune Tolerance / immunology
MicroRNAs / genetics*
T-Lymphocytes, Regulatory / immunology*

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding