Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors

Ping-Yen Liu; Po-Tseng Lee; Wei-Ting Chang; Yun-Ling Tai; Ting-Hsing Chao; Cheng-Han Lee; Yi-Heng Li; Jyh-Hong Chen; Liang-Miin Tsai; James K Liao

doi:10.1016/j.ijcard.2014.06.059

Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors

Int J Cardiol. 2014 Sep;176(1):250-3. doi: 10.1016/j.ijcard.2014.06.059. Epub 2014 Jul 6.

Authors

Ping-Yen Liu¹, Po-Tseng Lee², Wei-Ting Chang³, Yun-Ling Tai⁴, Ting-Hsing Chao⁵, Cheng-Han Lee⁶, Yi-Heng Li⁷, Jyh-Hong Chen⁸, Liang-Miin Tsai⁹, James K Liao¹⁰

Affiliations

¹ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: larry@mail.ncku.edu.tw.
² Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan; Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, Yun-Lin County, Taiwan. Electronic address: ptlee31@gmail.com.
³ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: weiting@info.hosp.ncku.edu.tw.
⁴ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: bunnylinn@gmail.com.
⁵ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: chaotinghsing@gmail.com.
⁶ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: appollolee@yahoo.com.tw.
⁷ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: t025215@ms17.hinet.net.
⁸ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: jyhhong@mail.ncku.edu.tw.
⁹ Division of Cardiology, Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Cardiovascular Research Center National Cheng-Kung University, Tainan, Taiwan. Electronic address: tsailm@mail.ncku.edu.tw.
¹⁰ Division of Cardiology, University of Chicago, IL, USA. Electronic address: jliao@medicine.bsd.uchicago.edu.

No abstract available

Keywords: Inflammation; Percutaneous coronary intervention; Rho kinase; Statin.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Enzyme Activation / drug effects
Enzyme Activation / physiology
Female
Genetic Pleiotropy / drug effects
Genetic Pleiotropy / physiology*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Leukocytes / drug effects
Leukocytes / enzymology*
Male
Middle Aged
Percutaneous Coronary Intervention / adverse effects*
Predictive Value of Tests
Preoperative Care* / methods
Treatment Outcome
rho-Associated Kinases / metabolism*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
rho-Associated Kinases

Publication types

MeSH terms

Substances

Grants and funding