HLA-DRB1*15:01 allele protects from asthma susceptibility

María Pino-Yanes; Almudena Corrales; Marialbert Acosta-Herrera; Eva Pérez-Rodríguez; José Cumplido; Paloma Campo; Amalia Barreto-Luis; Florentino Sánchez-García; Tobías Felipe; Inmaculada Sánchez-Machín; Inés Quintela; José Carlos García-Robaina; Jesús Villar; Miguel Blanca; Angel Carracedo; Teresa Carrillo; Carlos Flores

doi:10.1016/j.jaci.2014.05.031

HLA-DRB1*15:01 allele protects from asthma susceptibility

J Allergy Clin Immunol. 2014 Nov;134(5):1201-3. doi: 10.1016/j.jaci.2014.05.031. Epub 2014 Jul 14.

Authors

María Pino-Yanes¹, Almudena Corrales², Marialbert Acosta-Herrera³, Eva Pérez-Rodríguez⁴, José Cumplido⁵, Paloma Campo⁶, Amalia Barreto-Luis², Florentino Sánchez-García⁷, Tobías Felipe⁸, Inmaculada Sánchez-Machín⁹, Inés Quintela¹⁰, José Carlos García-Robaina⁴, Jesús Villar¹¹, Miguel Blanca⁶, Angel Carracedo¹², Teresa Carrillo⁵, Carlos Flores¹³

Affiliations

¹ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Department of Medicine, University of California, San Francisco, Calif.
² CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
³ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Research Unit, Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Hospital Universitario Dr Negrin, Gran Canaria, Spain.
⁴ Allergy Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
⁵ Allergy Unit, Hospital Universitario Dr Negrín, Gran Canaria, Spain.
⁶ Allergy Service, Carlos Haya Hospital, Malaga, Spain.
⁷ Immunology Unit, Hospital de Gran Canaria Dr Negrín, Gran Canaria, Spain.
⁸ NorthWest Research Associates, Boulder, Colo.
⁹ Allergy Unit, Hospital del Tórax, Complejo Hospitalario Universitario NS Candelaria, Tenerife, Spain.
¹⁰ Grupo de Medicina Xenómica, CEGEN-ISCIII-Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
¹¹ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Hospital Universitario Dr Negrin, Gran Canaria, Spain.
¹² Grupo de Medicina Xenómica, Fundación Galega de Medicina Xenómica (SERGAS)-CIBERER-Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
¹³ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address: cflores@ull.edu.es.

PMID: 25034406
DOI: 10.1016/j.jaci.2014.05.031

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Asthma / genetics*
Asthma / immunology
Female
Genetic Predisposition to Disease*
HLA-DRB1 Chains / genetics*
HLA-DRB1 Chains / immunology
Humans
Male
Polymorphism, Single Nucleotide*

Substances

HLA-DRB1 Chains
HLA-DRB1*15:01 antigen