Slow neuromodulation mediated by ATP P2X receptors

Ji Xu; Baljit S Khakh

doi:10.1016/j.neuron.2014.06.028

Slow neuromodulation mediated by ATP P2X receptors

Neuron. 2014 Jul 16;83(2):257-259. doi: 10.1016/j.neuron.2014.06.028.

Authors

Ji Xu¹, Baljit S Khakh²

Affiliations

¹ Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: bkhakh@mednet.ucla.edu.

Abstract

ATP-gated P2X receptors are widely expressed in the nervous system, but their physiological roles are not fully understood. New insights from Pougnet et al. (2014) in this issue of Neuron show that postsynaptic P2X receptors may be activated by ATP released from astrocytes and function to downregulate synaptic AMPA receptors in hippocampal neurons.

Publication types

Comment

MeSH terms

Adenosine Triphosphate / metabolism*
Animals
Hippocampus / metabolism*
Neurons / metabolism*
Receptors, AMPA / metabolism*
Receptors, Purinergic P2X / metabolism*
Synapses / metabolism*

Substances

Receptors, AMPA
Receptors, Purinergic P2X
Adenosine Triphosphate

Abstract

Publication types

MeSH terms

Substances

Grants and funding