Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A

Clin Mol Hepatol. 2014 Jun;20(2):204-7. doi: 10.3350/cmh.2014.20.2.204. Epub 2014 Jun 30.

Abstract

Pure red cell aplasia (PRCA) and autoimmune hemolytic anemia (AIHA) have rarely been reported as an extrahepatic manifestation of acute hepatitis A (AHA). We report herein a case of AHA complicated by both PRCA and AIHA. A 49-year-old female with a diagnosis of AHA presented with severe anemia (hemoglobin level, 6.9 g/dL) during her clinical course. A diagnostic workup revealed AIHA and PRCA as the cause of the anemia. The patient was treated with an initial transfusion and corticosteroid therapy. Her anemia and liver function test were completely recovered by 9 months after the initial presentation. We review the clinical features and therapeutic strategies for this rare case of extrahepatic manifestation of AHA.

Keywords: Autoimmune hemolytic anemia; Hepatitis A; Pure red-cell aplasia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Anemia, Hemolytic, Autoimmune / complications*
  • Anemia, Hemolytic, Autoimmune / diagnosis*
  • Anemia, Hemolytic, Autoimmune / drug therapy
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Bone Marrow / pathology
  • Female
  • Hepatitis A / complications*
  • Hepatitis A / diagnosis*
  • Humans
  • Male
  • Middle Aged
  • Prednisolone / therapeutic use
  • Red-Cell Aplasia, Pure / complications*
  • Red-Cell Aplasia, Pure / diagnosis*
  • Red-Cell Aplasia, Pure / drug therapy
  • Treatment Outcome
  • Young Adult

Substances

  • Antineoplastic Agents, Hormonal
  • Prednisolone