Relevance of PET for pretherapeutic prediction of doses in peptide receptor radionuclide therapy

Abstract

Personalized dosimetry in radionuclide therapy has gained much attention in recent years. This attention has also an impact on peptide receptor radionuclide therapy (PRRT). This article reviews the PET-based imaging techniques that can be used for pretherapeutic prediction of doses in PRRT. More specifically the usage of (86)Y, (90)Y, (68)Ga, and (44)Sc are discussed: their characteristics for PET acquisition, the available peptides for labeling, the specifics of the imaging protocols, and the experiences gained from phantom and clinical studies. These techniques are evaluated with regard to their usefulness for dosimetry predictions in PRRT, and future perspectives are discussed.

Keywords: Correlation with clinical response; Dosimetry; PET/CT; Peptide receptor radionuclide therapy; Planar imaging; Pretherapeutic treatment planning; Radiobiological models; SPECT/CT.