Morphology of susceptibility vessel sign predicts middle cerebral artery recanalization after intravenous thrombolysis

Stroke. 2014 Sep;45(9):2795-7. doi: 10.1161/STROKEAHA.114.006144. Epub 2014 Jul 15.

Abstract

Background and purpose: We aimed to evaluate the predictive value of susceptibility vessel sign (SVS) burden and morphology in middle cerebral artery recanalization.

Methods: We retrospectively examined clinical and imaging data from 72 consecutive patients with acute ischemic stroke with middle cerebral artery occlusion and examined the association of recanalization with SVS length and shape.

Results: None of the patients with a middle cerebral artery SVS >20 mm in length achieved recanalization. For patients with a relatively short SVS (length <20 mm), irregular shape was a strong independent predictor for no recanalization (odds ratio, 6.891; 95% confidence interval, 1.441-32.950; P=0.016).

Conclusions: Irregular shape and long length (>20 mm) of SVS decrease the potential to recanalize the occluded middle cerebral artery with intravenous thrombolysis.

Keywords: magnetic resonance imaging; middle cerebral artery; stroke; thrombolytic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravenous
  • Aged
  • Female
  • Humans
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Male
  • Middle Aged
  • Middle Cerebral Artery / anatomy & histology
  • Middle Cerebral Artery / physiopathology*
  • Predictive Value of Tests
  • Retrospective Studies
  • Thrombolytic Therapy / methods*
  • Treatment Outcome