Abstract
Chemical investigation of the stem bark and leaves of Putranjiva roxburghii has resulted in the isolation of a new ellagic acid glycoside (5) along with four saponins (1-4). The structures of the isolated compounds were established by detailed spectral analysis. Incidentally putranoside-A methyl ester (4) has been isolated for the first time from this species and the saponins (1-4) exhibited potent DNA topoisomerase IB inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ellagic Acid / chemistry
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Ellagic Acid / isolation & purification*
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Ellagic Acid / pharmacology
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Euphorbiaceae / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Topoisomerase I Inhibitors / chemistry
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Topoisomerase I Inhibitors / isolation & purification*
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Topoisomerase I Inhibitors / pharmacology
Substances
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Glycosides
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Saponins
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Topoisomerase I Inhibitors
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Ellagic Acid