A new ellagic acid glycoside and DNA topoisomerase IB inhibitory activity of saponins from Putranjiva roxburghii

Nat Prod Commun. 2014 May;9(5):675-7.

Abstract

Chemical investigation of the stem bark and leaves of Putranjiva roxburghii has resulted in the isolation of a new ellagic acid glycoside (5) along with four saponins (1-4). The structures of the isolated compounds were established by detailed spectral analysis. Incidentally putranoside-A methyl ester (4) has been isolated for the first time from this species and the saponins (1-4) exhibited potent DNA topoisomerase IB inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ellagic Acid / chemistry
  • Ellagic Acid / isolation & purification*
  • Ellagic Acid / pharmacology
  • Euphorbiaceae / chemistry*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Topoisomerase I Inhibitors / chemistry
  • Topoisomerase I Inhibitors / isolation & purification*
  • Topoisomerase I Inhibitors / pharmacology

Substances

  • Glycosides
  • Saponins
  • Topoisomerase I Inhibitors
  • Ellagic Acid