Activities of daily living, depression, and quality of life in Parkinson's disease

Blake J Lawrence; Natalie Gasson; Robert Kane; Romola S Bucks; Andrea M Loftus

doi:10.1371/journal.pone.0102294

Activities of daily living, depression, and quality of life in Parkinson's disease

PLoS One. 2014 Jul 15;9(7):e102294. doi: 10.1371/journal.pone.0102294. eCollection 2014.

Authors

Blake J Lawrence¹, Natalie Gasson², Robert Kane¹, Romola S Bucks³, Andrea M Loftus²

Affiliations

¹ Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia.
² Curtin Neuroscience Laboratory, School of Psychology and Speech Pathology, Curtin University, Perth, Western Australia, Australia; Parkinson's Centre (ParkC), Curtin University, Perth, Western Australia, Australia.
³ Parkinson's Centre (ParkC), Curtin University, Perth, Western Australia, Australia; School of Psychology, University of Western Australia, Perth, Western Australia, Australia.

Abstract

This study examined whether activities of daily living (ADL) mediate the relationship between depression and health-related quality of life (HR-QOL) in people with Parkinson's disease (PD). A cross-sectional, correlational research design examined data from 174 participants who completed the Geriatric Depression Scale (GDS-15), Parkinson's Disease Questionnaire-39 (PDQ-39), and Unified Parkinson's Disease Rating Scale-section 2 (UPDRS-section 2 [ADL]). Multiple Regression Analysis (MRA) was used to examine the mediator model. Depression and ADL significantly (p<.001) predicted HR-QOL, and depression significantly (p<.001) predicted ADL. Whilst ADL did not impact on the relationship between depression and HR-QOL, there was a significant (p<.001) indirect effect of depression on HR-QOL via ADL, suggesting both direct and indirect (via ADL) effects of depression on HR-QOL. The magnitude of this effect was moderate (R2 = .13). People with PD who report depression also experience greater difficulty completing ADL, which impacts upon their HR-QOL. It is recommended that clinicians adopt a multidisciplinary approach to care by combining pharmacological treatments with psycho/occupational therapy, thereby alleviating the heterogeneous impact of motor and non-motor symptoms on HR-QOL in people with PD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Activities of Daily Living*
Adult
Aged
Aged, 80 and over
Depression / complications*
Female
Humans
Male
Middle Aged
Parkinson Disease / complications
Parkinson Disease / physiopathology*
Quality of Life*

Grants and funding

All funding for ParkC has been received from the Australian Research Council, Edith Cowan University's Office of Research and Innovation, Parkinson's Association of WA, The McCusker Charitable Foundation, Parkinson's Young Onset Support Group (WA) and the Royal Freshwater Bay Yacht Club. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.