Scavenging and characterization of short-lived radicals using a novel stable nitroxide radical with a characteristic UV-vis absorption spectrum

Ryuta Toba; Hiroaki Gotoh; Kazuhisa Sakakibara

doi:10.1021/ol501328k

Scavenging and characterization of short-lived radicals using a novel stable nitroxide radical with a characteristic UV-vis absorption spectrum

Org Lett. 2014 Aug 1;16(15):3868-71. doi: 10.1021/ol501328k. Epub 2014 Jul 14.

Authors

Ryuta Toba¹, Hiroaki Gotoh, Kazuhisa Sakakibara

Affiliation

¹ Department of Applied Chemistry, Yokohama National University , 79-5 Tokiwadai, Hodogayaku, Yokohama 240-8501 Japan.

PMID: 25019641
DOI: 10.1021/ol501328k

Abstract

A stable tert-butyl(10-phenyl-9-anthryl)nitroxide (BPAN) radical was newly synthesized and used for the capture/characterization of reactive radicals. Adducts obtained from the reactions of BPAN with in situ generated reactive radicals showed excellent stability, assuring complete isolation and purification. The structures of the adducts were established by LC-MS and NMR analyses.