An activatable, polarity dependent, dual-luminescent imaging agent with a long luminescence lifetime

Chem Commun (Camb). 2014 Sep 4;50(68):9733-6. doi: 10.1039/c4cc04015e.

Abstract

In this proof-of-concept study, a new activatable imaging agent based on two luminophores and two different quenching mechanisms is reported. Both partial and total activation of the luminescence signal can be achieved, either in solution or in vitro. Bond cleavage makes the compound suitable for luminescence lifetime imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / diagnosis
  • Carbocyanines / chemistry*
  • Cell Line
  • Cell Line, Tumor
  • Coordination Complexes / chemistry*
  • Female
  • Iridium / chemistry*
  • Luminescence
  • Luminescent Agents / chemistry*
  • Luminescent Measurements
  • Mice
  • Microscopy, Confocal
  • Neoplasms / diagnosis
  • Optical Imaging

Substances

  • Carbocyanines
  • Coordination Complexes
  • Luminescent Agents
  • cyanine dye 5
  • Iridium