Abstract
One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens). We briefly discuss here three antiretroviral restriction factors in mice: Fv1, APOBEC3, and tetherin, touching on both biological and molecular aspects of these restriction systems.
Keywords:
APOBEC3; Fv1 restriction; Murine leukemia virus; Retrovirus; Tetherin.
Published by Elsevier B.V.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Antigens, CD / genetics
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Antigens, CD / metabolism
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Cytidine Deaminase / genetics
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Cytidine Deaminase / metabolism
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Host-Pathogen Interactions / immunology*
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Immunity, Innate*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism
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Mice
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Proteins / genetics
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Proteins / metabolism
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Retroviridae / physiology*
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Retroviridae Infections / genetics
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Retroviridae Infections / immunology*
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Retroviridae Infections / metabolism
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Retroviridae Infections / virology*
Substances
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Antigens, CD
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BST2 protein, mouse
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Fv1 protein, mouse
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Membrane Glycoproteins
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Proteins
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Apobec3 protein, mouse
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Cytidine Deaminase