Association between dopa decarboxylase gene variants and borderline personality disorder

Arian Mobascher; Martin Bohus; Norbert Dahmen; Lydie Dietl; Ina Giegling; Martin Jungkunz; Nikolaus Kleindienst; Matthias Limberger; Eva Meisenzahl; Marcella Rietschel; Stefan Roepke; Christian Schmahl; Björn Schott; Cornelia E Schwarze; André Tadić; Jens Treutlein; Friederike Vogel; Stephanie H Witt; Thomas Zetzsche; Dan Rujescu; Klaus Lieb

doi:10.1016/j.psychres.2014.06.031

Association between dopa decarboxylase gene variants and borderline personality disorder

Psychiatry Res. 2014 Nov 30;219(3):693-5. doi: 10.1016/j.psychres.2014.06.031. Epub 2014 Jun 28.

Authors

Arian Mobascher¹, Martin Bohus², Norbert Dahmen³, Lydie Dietl⁴, Ina Giegling⁵, Martin Jungkunz², Nikolaus Kleindienst², Matthias Limberger², Eva Meisenzahl⁶, Marcella Rietschel⁷, Stefan Roepke⁴, Christian Schmahl², Björn Schott⁸, Cornelia E Schwarze³, André Tadić³, Jens Treutlein⁷, Friederike Vogel³, Stephanie H Witt⁷, Thomas Zetzsche⁶, Dan Rujescu⁵, Klaus Lieb³

Affiliations

¹ Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany. Electronic address: arian.mobascher@unimedizin-mainz.de.
² Department of Psychosomatic Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
³ Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany.
⁴ Department of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany.
⁵ Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany; Department of Psychiatry and Psychotherapy, Martin-Luther University Halle-Wittenberg, Germany.
⁶ Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
⁷ Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
⁸ Department of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany.

PMID: 25017620
DOI: 10.1016/j.psychres.2014.06.031

Abstract

Despite heritability estimates of 37-69%, research has identified few genetic risk variants for borderline personality disorder (BPD). The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene.

Keywords: Borderline personality disorder; Dopa decarboxylase; Single nucleotide polymorphism.

MeSH terms

Adult
Alleles
Borderline Personality Disorder / diagnosis
Borderline Personality Disorder / epidemiology*
Borderline Personality Disorder / genetics*
Case-Control Studies
Dopa Decarboxylase / genetics*
Female
Genetic Variation
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*

Substances

Dopa Decarboxylase