Racial/ethnic disparities in human DNA methylation

Biochim Biophys Acta. 2014 Aug;1846(1):258-62. doi: 10.1016/j.bbcan.2014.07.001. Epub 2014 Jul 10.

Abstract

The racial/ethnic disparities in DNA methylation patterns indicate that molecular markers may play a role in determining the individual susceptibility to diseases in different ethnic groups. Racial disparities in DNA methylation patterns have been identified in prostate cancer, breast cancer and colorectal cancer and are related to racial differences in cancer prognosis and survival.

Keywords: Cancer; DNA methylation; Individual susceptibility; Racial/ethnic disparities.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / ethnology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / mortality
  • Colorectal Neoplasms / ethnology
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / mortality
  • DNA Methylation*
  • Ethnicity*
  • Female
  • Humans
  • Lung Neoplasms / ethnology
  • Lung Neoplasms / genetics
  • Lung Neoplasms / mortality
  • Male
  • Neoplasms / ethnology*
  • Neoplasms / genetics*
  • Neoplasms / mortality
  • Prostatic Neoplasms / ethnology
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / mortality
  • Racial Groups*