Targeted biopharmaceuticals for cancer treatment

Lufang Zhou; Ningning Xu; Yan Sun; Xiaoguang Margaret Liu

doi:10.1016/j.canlet.2014.06.020

Targeted biopharmaceuticals for cancer treatment

Cancer Lett. 2014 Oct 1;352(2):145-51. doi: 10.1016/j.canlet.2014.06.020. Epub 2014 Jul 9.

Authors

Lufang Zhou¹, Ningning Xu², Yan Sun³, Xiaoguang Margaret Liu⁴

Affiliations

¹ Departments of Medicine and Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
² Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA.
³ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China; Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
⁴ Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China. Electronic address: mliu@eng.ua.edu.

PMID: 25016064
DOI: 10.1016/j.canlet.2014.06.020

Abstract

Cancer is a complex invasive genetic disease that causes significant mortality rate worldwide. Protein-based biopharmaceuticals have significantly extended the lives of millions of cancer patients. This article reviews the biological function and application of targeted anticancer biopharmaceuticals. We first discuss the specific antigens and core pathways that are used in the development of targeted cancer therapy. The innovative monoclonal antibodies, non-antibody proteins, and small molecules targeting these antigens or pathways are then reviewed. Finally, the current challenges in anticancer biopharmaceuticals development and the potential solutions to address these challenges are discussed.

Keywords: Anticancer biopharmaceuticals; Biosimilar; Innovative biologics; Targeted therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antibodies, Monoclonal / therapeutic use
Antineoplastic Agents / therapeutic use*
Biological Products / therapeutic use*
Biosimilar Pharmaceuticals / therapeutic use
Drug Design*
Drugs, Generic / therapeutic use
Humans
Male
Molecular Targeted Therapy*
Neoplasms / drug therapy*
Neoplasms / immunology
Neoplasms / metabolism
Neoplasms / pathology
Proteins / therapeutic use
Signal Transduction / drug effects

Substances

Antibodies, Monoclonal
Antineoplastic Agents
Biological Products
Biosimilar Pharmaceuticals
Drugs, Generic
Proteins