Interactions between HIV-1 and the cell-autonomous innate immune system

Greg J Towers; Mahdad Noursadeghi

doi:10.1016/j.chom.2014.06.009

Interactions between HIV-1 and the cell-autonomous innate immune system

Cell Host Microbe. 2014 Jul 9;16(1):10-8. doi: 10.1016/j.chom.2014.06.009.

Authors

Greg J Towers¹, Mahdad Noursadeghi²

Affiliations

¹ Division of Infection and Immunity, University College London, London W1CE 6BT, UK. Electronic address: g.towers@ucl.ac.uk.
² Division of Infection and Immunity, University College London, London W1CE 6BT, UK.

Abstract

HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

HIV-1 / immunology*
Host-Pathogen Interactions*
Humans
Immune Evasion*
Immunity, Innate*

Abstract

Publication types

MeSH terms

Grants and funding