Abstract
For the first time TFAA/H3PO4 has facilitated the direct and metal-free N-acylation of carbazoles leading to a number of N-acylated derivatives. Several of these compounds were found to be promising when tested for their anti-proliferative properties against oral cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Anhydrides / chemistry*
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Acylation
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Carbazoles / pharmacology*
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Carboxylic Acids / chemistry
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Fluoroacetates / chemistry*
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HEK293 Cells
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Humans
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Neoplasms / pathology*
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Phosphoric Acids / chemistry*
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / pharmacology*
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Stereoisomerism
Substances
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Acetic Anhydrides
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Carbazoles
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Carboxylic Acids
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Fluoroacetates
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Phosphoric Acids
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Small Molecule Libraries
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trifluoroacetic anhydride
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phosphoric acid