Isolation, structural analyses and biological activity assays against chronic lymphocytic leukemia of two novel cytochalasins - sclerotionigrin A and B

Molecules. 2014 Jul 8;19(7):9786-97. doi: 10.3390/molecules19079786.

Abstract

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cytochalasins / chemistry*
  • Cytochalasins / isolation & purification
  • Cytochalasins / pharmacology*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Antineoplastic Agents
  • Cytochalasins
  • sclerotionigrin B