Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits

Emanuela Ortolani; Massimiliano Guerriero; Antonella Coli; Amalia Di Giannuario; Gianluca Minniti; Antonella Polimeni

Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits

Ann Stomatol (Roma). 2014 Jun 18;5(2):66-8. eCollection 2014 Apr.

Authors

Emanuela Ortolani¹, Massimiliano Guerriero², Antonella Coli³, Amalia Di Giannuario⁴, Gianluca Minniti⁵, Antonella Polimeni⁶

Affiliations

¹ General Dentistry and Emergency Care Unit George Eastman Dental Hospital, Rome, Italy.
² Laboratory of Pathology, A. Cardarelli Hospital, Campobasso, Italy.
³ Institute of Pathology, Sacro Cuore Cattolica University, Rome, Italy.
⁴ Istituto Superiore di Sanita (ISS), Rome, Italy.
⁵ Private practice, Rome, Italy.
⁶ Department of Oral and Maxillo-facial Sciences, Pediatric Dentistry Unit, Sapienza University of Rome, Italy.

PMID: 25002920
PMCID: PMC4071363

Abstract

The ability of platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1) and platelet-rich plasma (PRP) to increase the rate of osseointegration of endosseous implants and to improve the quality of bone remodeling on the surface of titanium, has been investigated in an experimental intraosseous defect model by an histological and immunohistochemical evaluation. The results from this study demonstrate that rabbits treated with the combination PDGF/IGF-1 showed a higher positive effect on bone regeneration than PRP-treated or controls.

Keywords: IGF-1; PDGF; PRP; bone formation; dental implants; growth factors.