[Immune function of interleukin-33 and its relation to human diseases]

Bi-jun Cui; Qing-qing Wang

doi:10.3785/j.issn.1008-9292.2014.04.004

[Immune function of interleukin-33 and its relation to human diseases]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2014 May;43(3):366-71. doi: 10.3785/j.issn.1008-9292.2014.04.004.

[Article in Chinese]

Authors

Bi-jun Cui¹, Qing-qing Wang¹

Affiliation

¹ Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.

PMID: 24998663
DOI: 10.3785/j.issn.1008-9292.2014.04.004

Abstract

Interleukin-33 (IL-33) is a novel cytokine and belongs to IL-1 family expressed in a wide range of organs and cells. IL-33 is a dual-functional molecule: as a classical cytokine it induces immune response and it also regulates gene transcription in the nucleus. Altered expression of IL-33 has been observed in various human diseases such as inflammation, autoimmune diseases, and virus infection. The article reviews advances on immune function of IL-33 and its relation to a variety of human diseases.

Publication types

English Abstract
Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoimmune Diseases / immunology
Humans
Inflammation / immunology
Interleukin-33
Interleukins / immunology*

Substances

IL33 protein, human
Interleukin-33
Interleukins