[Prophylactic, preemptive and curative use of donor lymphocyte infusion in patients undergoing allogeneic stem cell transplantation: guidelines of the SFGM-TC]

Pathol Biol (Paris). 2014 Aug;62(4):193-6. doi: 10.1016/j.patbio.2014.05.011. Epub 2014 Jul 1.
[Article in French]

Abstract

In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapy (SFGM-TC) set up the fourth annual series of workshops which brought together practitioners from all member centers and took place in September 2013 in Lille. Here, we report our recommendations regarding the use of donor lymphocyte injection (DLI) in the prophylactic, pre-emptive and curative settings. This work has been limited to allogeneic stem cell transplantations from an HLA-matched (10/10) or -one antigen-mismatched (9/10) donor.

Keywords: Cell therapies; Curatif; Curative; Donor lymphocyte injection; Immunotherapy post-allogeneic transplantation; Immunothérapie post-allogreffe; Injection de lymphocytes du donneur; Preemptive; Prophylaxie; Prophylaxis; Préemptif; Thérapie cellulaire.

Publication types

  • English Abstract
  • Practice Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Haplotypes
  • Histocompatibility Testing
  • Humans
  • Lymphocyte Transfusion*
  • Recurrence
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / standards*
  • Tissue and Organ Procurement
  • Transplantation, Homologous / methods
  • Transplantation, Homologous / standards*