Synthetic methodologies in organic chemistry involving incorporation of [¹⁷O] and [¹⁸O] isotopes

Vassiliki Theodorou; Konstantinos Skobridis; Dimitrios Alivertis; Ioannis P Gerothanassis

doi:10.1002/jlcr.3212

Synthetic methodologies in organic chemistry involving incorporation of [¹⁷O] and [¹⁸O] isotopes

J Labelled Comp Radiopharm. 2014 Jun 30;57(8):481-508. doi: 10.1002/jlcr.3212. Epub 2014 Jul 3.

Authors

Vassiliki Theodorou¹, Konstantinos Skobridis, Dimitrios Alivertis, Ioannis P Gerothanassis

Affiliation

¹ Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, GR-451 10, Greece.

PMID: 24996002
DOI: 10.1002/jlcr.3212

Abstract

This review is a critical survey of the literature that aims to highlight the most significant developments on synthetic strategies involving stable oxygen isotopes ([(17)O] and [(18)O]). The labeling methodologies are categorized in groups, according to the oxygen-containing functional group.

Keywords: [17O]; [18O] enrichment; labeled compound; oxygen isotopes; synthesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemistry Techniques, Synthetic / methods
Oxygen Isotopes / chemistry
Radiopharmaceuticals / chemical synthesis*
Radiopharmaceuticals / chemistry

Substances

Oxygen Isotopes
Radiopharmaceuticals