Protein-protein interactions and human cellular cofactors as new targets for HIV therapy

Cristina Tintori; Annalaura Brai; Anna Lucia Fallacara; Roberta Fazi; Silvia Schenone; Maurizio Botta

doi:10.1016/j.coph.2014.06.005

Protein-protein interactions and human cellular cofactors as new targets for HIV therapy

Curr Opin Pharmacol. 2014 Oct:18:1-8. doi: 10.1016/j.coph.2014.06.005. Epub 2014 Jul 1.

Authors

Cristina Tintori¹, Annalaura Brai¹, Anna Lucia Fallacara², Roberta Fazi¹, Silvia Schenone³, Maurizio Botta⁴

Affiliations

¹ Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
² Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Chimica e Tecnologie Farmaceutiche, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.
³ Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV 3, I-16132 Genova, Italy.
⁴ Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA 19122, USA. Electronic address: botta.maurizio@gmail.com.

PMID: 24993074
DOI: 10.1016/j.coph.2014.06.005

Abstract

Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein-protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptor Proteins, Signal Transducing / metabolism
Anti-HIV Agents / pharmacology
Anti-HIV Agents / therapeutic use
CD4 Antigens / metabolism
DEAD-box RNA Helicases / metabolism
HIV Envelope Protein gp120 / metabolism
HIV Infections / drug therapy*
HIV Infections / metabolism
HIV Integrase
Humans
Protein-Tyrosine Kinases / metabolism
Receptors, CCR5 / metabolism
Transcription Factors / metabolism

Substances

Adaptor Proteins, Signal Transducing
Anti-HIV Agents
CCR5 protein, human
CD4 Antigens
HIV Envelope Protein gp120
PSIP1 protein, human
Receptors, CCR5
Transcription Factors
gp120 protein, Human immunodeficiency virus 1
Protein-Tyrosine Kinases
HIV Integrase
DDX3X protein, human
DEAD-box RNA Helicases
p31 integrase protein, Human immunodeficiency virus 1