Application of EPR dosimetry in bone for ex vivo measurements of doses in radiotherapy patients

Radiat Prot Dosimetry. 2014 Nov;162(1-2):38-42. doi: 10.1093/rpd/ncu214. Epub 2014 Jul 3.

Abstract

In the present study, bone samples from three patients treated in radiotherapy facilities in Poland were used for the determination of doses absorbed during radiotherapy. The samples were obtained during surgical treatments of patients performed due to medical indications. For the purpose of retrospective dosimetry, sensitivity of the radiation-induced EPR signal was individually calibrated in the samples by re-irradiation of the samples with known doses. The doses reconstructed in bones extracted within 6 months after irradiation were consistent with those calculated by treatment planning systems. The dose reconstructed in the bone removed 6 y after radiotherapy was ∼14% lower than the calculated one.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Neoplasms / radiotherapy*
  • Bone Neoplasms / secondary
  • Bone and Bones / radiation effects*
  • Electron Spin Resonance Spectroscopy / methods*
  • Humans
  • Lip Neoplasms / pathology
  • Lip Neoplasms / radiotherapy
  • Mouth Neoplasms / pathology
  • Mouth Neoplasms / radiotherapy
  • Radiometry / methods*
  • Radiotherapy Dosage