Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics

Tatyana V Abramova; Sergey S Belov; Yulia V Tarasenko; Vladimir N Silnikov

doi:10.3762/bjoc.10.115

Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics

Beilstein J Org Chem. 2014 May 20:10:1151-8. doi: 10.3762/bjoc.10.115. eCollection 2014.

Authors

Tatyana V Abramova¹, Sergey S Belov², Yulia V Tarasenko¹, Vladimir N Silnikov¹

Affiliations

¹ Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia.
² Institute of Chemical Biology and Fundamental Medicine, SB RAS, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia ; Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia.

Abstract

An efficient solid-phase-supported peptide synthesis (SPPS) of morpholinoglycine oligonucleotide (MorGly) mimics has been developed. The proposed strategy includes a novel specially designed labile linker group containing the oxalyl residue and the 2-aminomethylmorpholino nucleoside analogues as first subunits.

Keywords: labile linker; morpholino oligomers; oligonucleotide mimics; solid-phase-supported peptide synthesis (SPPS).