Cancer-targeted functional gold nanoparticles for apoptosis induction and real-time imaging based on FRET

Nanoscale. 2014 Aug 21;6(16):9531-5. doi: 10.1039/c4nr02516d.

Abstract

A versatile gold nanoparticle-based multifunctional RB-DEVD-AuNP-DTP has been developed to induce the targeted apoptosis of cancer cells and image in real time the progress of the apoptosis. The multifunctional nanoparticles were demonstrated to have the ability to initiate mitochondria-dependent apoptosis and activate caspase-3 for real-time imaging of the progression of apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects*
  • Drug Carriers / chemistry*
  • Drug Carriers / pharmacology
  • Fluorescence Resonance Energy Transfer
  • Gold / chemistry*
  • Gold / pharmacology
  • HeLa Cells
  • Humans
  • Metal Nanoparticles / chemistry*

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Gold