Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Don P Wolf; Shoukhrat Mitalipov

doi:10.1016/j.cmet.2014.06.012

Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Cell Metab. 2014 Jul 1;20(1):6-8. doi: 10.1016/j.cmet.2014.06.012.

Authors

Don P Wolf¹, Shoukhrat Mitalipov²

Affiliations

¹ Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA.
² Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, 505 Northwest 185(th) Avenue, Beaverton, OR 97006, USA. Electronic address: mitalipo@ohsu.edu.

Abstract

Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

Publication types

Comment

MeSH terms

Animals
Humans
Mitochondrial Diseases / genetics*
Mitochondrial Diseases / prevention & control*
Nuclear Transfer Techniques*
Oocytes / cytology*
Polar Bodies / transplantation*

Abstract

Publication types

MeSH terms

Grants and funding