Turning cell cycle entry on its head

Cosetta Bertoli; Robertus Antonius Maria de Bruin

doi:10.7554/eLife.03475

Turning cell cycle entry on its head

Elife. 2014 Jul 1:3:e03475. doi: 10.7554/eLife.03475.

Authors

Cosetta Bertoli¹, Robertus Antonius Maria de Bruin²

Affiliations

¹ Cosetta Bertoli is at the MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
² Robertus Antonius Maria de Bruin is at the MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom r.debruin@ucl.ac.uk.

Abstract

New data on the relationship between two proteins, cyclin D and Rb, suggest that we need to re-evaluate our understanding of how cells enter into the cell cycle.

Keywords: CDK; DNA replication stress; G1/S transcription; cell cycle; checkpoint; genome integrity.

Publication types

Comment

MeSH terms

Animals
Cyclin D1 / metabolism*
Humans
Retinoblastoma Protein / metabolism*

Substances

Retinoblastoma Protein
Cyclin D1

Grants and funding

G0800297/MRC_/Medical Research Council/United Kingdom