Abstract
Background:
Drug monitoring is a useful tool for obtaining detailed information about the disposition of a drug in an individual patient during chemotherapy. According to the international guidelines, the analytical assay for quantification of a compound in biological samples must be validated. Among a number of parameters, peak purity is an important requirement.
Materials and methods:
We analyzed pharmacokinetics in patients who received chemotherapy with capecitabine and up to 10 various co-medications.
Results:
Out of seven investigated co-administered drugs, we found evidence that the proton pump inhibitor pantoprazole causes peak interferences with capecitabine during high-performance liquid chromatography analysis. Therefore quantification of capecitabine in plasma samples can be inaccurate.
Conclusion:
We recommend an altered time schedule for co-administered drugs or changing the mobile phase used in the assay.
Keywords:
Capecitabine; HPLC; interaction; metabolites; pantoprazole; premedication.
Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles / administration & dosage
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2-Pyridinylmethylsulfinylbenzimidazoles / blood
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2-Pyridinylmethylsulfinylbenzimidazoles / pharmacokinetics
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / blood*
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Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
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Capecitabine
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Chromatography, High Pressure Liquid / methods
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Colorectal Neoplasms / blood*
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Colorectal Neoplasms / drug therapy*
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / blood
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Deoxycytidine / pharmacokinetics
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Drug Administration Schedule
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Drug Interactions
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Drug Monitoring / methods*
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Floxuridine / blood*
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Fluorouracil / administration & dosage
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Fluorouracil / analogs & derivatives*
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Fluorouracil / blood
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Fluorouracil / pharmacokinetics
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Humans
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Pantoprazole
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Proton Pump Inhibitors / administration & dosage
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Proton Pump Inhibitors / blood
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Proton Pump Inhibitors / pharmacokinetics
Substances
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2-Pyridinylmethylsulfinylbenzimidazoles
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Proton Pump Inhibitors
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Floxuridine
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Deoxycytidine
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Capecitabine
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5'-deoxy-5-fluorocytidine
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Pantoprazole
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Fluorouracil
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doxifluridine