1 Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
2 Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada. Electronic address: neill.adhikari@utoronto.ca.