Physiology-based pharmacokinetic modeling: ready to be used

Walter Schmitt; Stefan Willmann

doi:10.1016/j.ddtec.2005.01.001

Physiology-based pharmacokinetic modeling: ready to be used

Drug Discov Today Technol. 2005 Spring;2(1):125-32. doi: 10.1016/j.ddtec.2005.01.001.

Authors

Walter Schmitt¹, Stefan Willmann²

Affiliations

¹ Bayer Technology Services GmbH, Competence Center Biophysics, D-51368 Leverkusen, Germany. Electronic address:walter.schmitt@bayertechnology.com.
² Bayer Technology Services GmbH, Competence Center Biophysics, D-51368 Leverkusen, Germany.

PMID: 24981765
DOI: 10.1016/j.ddtec.2005.01.001

Abstract

Physiology-based pharmacokinetic (PBPK) modeling is well recognized as a technology for mechanistically simulating and predicting the fate of substances in a mammalian body. Today, the demand for this methodology is higher than ever. The pharma industry and regulatory agencies are looking for new methods, which help to speed up and increase the efficiency of the development process for new drugs. Implementing PBPK modeling in the drug research and development workflow contributes significantly to reach this goal.: