Advanced nanovehicles for cancer management

Drug Discov Today. 2014 Oct;19(10):1659-70. doi: 10.1016/j.drudis.2014.06.020. Epub 2014 Jun 27.

Abstract

Over the past decade, together with the improvement of traditional cancer treatments, conveniently designed (with respect to their size, shape, main material, and coating) and specifically targeted nanovehicles have been developed. Nano-sized carriers can be functionalized to recognize key structures expressed in cancer cells and/or their surrounding tissues. Recently, some more complex systems have been developed that exploit the human body's own communication systems to enhance their efficacy. Some of the newest nanoparticles have the capacity to not only serve as drug delivery systems for a myriad of molecules, but also operate as direct cancer treatment agents themselves, such as in thermal therapies. In this review, we highlight the most recent advances in nanotechnology for treating cancer and address some of the challenges and opportunities in the field.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Drug Carriers / administration & dosage*
  • Humans
  • Immunotherapy
  • Magnetic Phenomena
  • Nanoparticles / administration & dosage*
  • Neoplasms / drug therapy
  • Neoplasms / therapy*
  • Nucleic Acids / administration & dosage
  • Photochemotherapy

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Nucleic Acids