A meta-analysis of surgical versus nonsurgical management of recurrent thymoma

Masatsugu Hamaji; Syed Osman Ali; Bryan M Burt

doi:10.1016/j.athoracsur.2014.04.028

A meta-analysis of surgical versus nonsurgical management of recurrent thymoma

Ann Thorac Surg. 2014 Aug;98(2):748-55. doi: 10.1016/j.athoracsur.2014.04.028. Epub 2014 Jun 28.

Authors

Masatsugu Hamaji¹, Syed Osman Ali², Bryan M Burt³

Affiliations

¹ Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan. Electronic address: mhamaji@kuhp.kyoto-u.ac.jp.
² Division of Cardiothoracic Surgery, Altru Hospital, Grand Forks, North Dakota.
³ Department of Cardiothoracic Surgery, Division of Thoracic Surgery, Stanford University Medical School, Stanford, California.

PMID: 24980604
DOI: 10.1016/j.athoracsur.2014.04.028

Abstract

This meta-analysis was designed to determine the effect of surgical and nonsurgical approaches on 5-year and 10-year overall survival (OS) in patients with recurrent thymoma. PubMed, Scopus, and the Journal of Japanese Association for Chest Surgery were queried, and 11 studies were eligible. Our meta-analysis using a random-effect model revealed significant differences in the rates of 5- and 10-year OS after thymectomy and in 5-year OS after recurrence, favoring surgically managed patients. Surgical resection may be associated with improved long-term survival and should be considered for patients with recurrent thymoma.

Publication types

Comparative Study
Meta-Analysis
Review

MeSH terms

Checklist
Humans
Survival Rate
Thymectomy
Thymoma / mortality
Thymoma / surgery
Thymoma / therapy*
Thymus Neoplasms / mortality
Thymus Neoplasms / surgery
Thymus Neoplasms / therapy*