Non-thermal plasmas: novel preventive and curative therapy against melanomas?

Exp Dermatol. 2014 Oct;23(10):716-7. doi: 10.1111/exd.12481.

Abstract

Malignant melanoma is a very aggressive cancer with a very poor short-term prognosis once metastatic. For years, there was no efficient adjuvant therapy after surgery. Chemotherapy and immunotherapy provided hope, but not victory. Further efforts are therefore required, to find new ways to cure this disease. Physics has, once again, opened up new possibilities for treatment, through the use of non-equilibrium atmospheric pressure plasma (NEAPP). The curative potential of this technique was initially assessed on cancer cells, among which melanoma. In a recent issue, Yajima et al. use NEAPP on benign nevi, as a preventive treatment.

Keywords: CAP; NEAPP; nevi; prevention; treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Argon / therapeutic use*
  • Cell Cycle Proteins / genetics*
  • Gene Expression Regulation, Neoplastic / radiation effects*
  • Nevus, Pigmented / genetics*
  • Proto-Oncogene Proteins c-ret / genetics*
  • Radiotherapy / methods*
  • Skin Neoplasms / genetics*

Substances

  • Cell Cycle Proteins
  • Argon
  • Proto-Oncogene Proteins c-ret