Multichannel imaging systems currently feature refocusing capabilities only in bulky and expensive designs. Mechanical movements of the components cannot be integrated in miniaturized designs, preventing classical refocusing mechanisms. To overcome this limitation we developed, as a proof-of-concept (POC) demonstration, a compact low-cost two-channel refocusing imaging system based on a voltage-tunable liquid lens. In addition, the design can be realized with wafer-level manufacturing techniques. One channel of the imaging system enables a wide field of view (FOV) of a scene (2×40°) but with a limited angular resolution (0.078°), while the other channel gives a high angular resolution (0.0098°) image of a small region of interest but with a much narrower FOV (2×7.57°). It is this high-resolution channel that contains the tunable lens and therefore the refocusing capability. A POC demonstration of the proposed two-channel system was built and its performances were measured. Both imaging channels show good overall diffraction-limited image quality.